We study the diverse functions of the immune response and try to understand the genetic and environmental factors that influence T cell development and differentiation. To find out more about the immune system, we use the latest gene detection methods, computational approaches and sophisticated disease models of allergy and cancer. In 2023, we are making a move to the Leo Foundation Skin Immunology Centre at Copenhagen University where we will focus on immune responses in lesional skin diseases.
Classon CH, Li M, Clavero AL, Ma J, Feng X, Tibbitt CA, Stark JM, Cardoso R, Ringqvist E, Boon L, Villablanca EJ, Rothfuchs AG, Eidsmo L, Coquet JM, Nylén S. Intestinal helminth infection transforms the CD4+ T cell composition of the skin. Mucosal Immunol. 2022 Feb;15(2):257-267. doi: 10.1038/s41385-021-00473-9. Epub 2021 Dec 20. PubMed PMID: 34931000; PubMed Central PMCID: PMC8866128.
Sheward DJ, Mandolesi M, Urgard E, Kim C, Hanke L, Perez Vidakovics L, Pankow A, Smith NL, Castro Dopico X, McInerney GM, Coquet JM, Karlsson Hedestam GB, Murrell B. Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models. Cell Rep Med. 2021 Nov 16;2(11):100450. doi: 10.1016/j.xcrm.2021.100450. Epub 2021 Oct 23. PubMed PMID: 34723224; PubMed Central PMCID: PMC8536561.
Stark JM, Coquet JM, Tibbitt CA. The Role of PPAR-γ in Allergic Disease. Curr Allergy Asthma Rep. 2021 Oct 25;21(11):45. doi: 10.1007/s11882-021-01022-x. Review. PubMed PMID: 34697644; PubMed Central PMCID: PMC8545719.
Rohrbeck L, Adori M, Wang S, He C, Tibbitt CA, Chernyshev M, Sirel M, Ribacke U, Murrell B, Bohlooly-Y M, Karlsson MC, Karlsson Hedestam GB, Coquet JM. GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens. Immunol Cell Biol. 2021 Feb;99(2):234-243. doi: 10.1111/imcb.12399. Epub 2020 Sep 28. PubMed PMID: 32888232
Seitz C, Liu S, Klocke K, Joly AL, Czarnewski PV, Tibbitt C, Parigi SM, Westerberg LS, Coquet JM, Villablanca EJ, Wing K, Andersson J. Multi-faceted inhibition of dendritic cell function by CD4+Foxp3+regulatory T cells. J Autoimmunity. 2019 Jan 4. pii: S0896-8411(18)30438-4. doi: 10.1016/j.jaut.2018.12.002. PubMed PMID: 30616979 Link
Feng X, Classon C, Yang G, Lei L, Chan S, Rothfuchs A, Coquet JM and Nylén S. Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic nematode infection. Plos Pathogens. 2018. May 17; 14(5):e1007008. PMID: 29772005 Link
Centa M, Prokopec KE, Garimella M, Habir K, Hofste L, Stark J, Dahdah A, Tibbitt C, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI and Malin S. Acute loss of Apolipoprotein E triggers an autoimmune response that accelerates atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology. 2018. Jun 7. DOI: 10.1161/ATVBAHA.118.310802. PMID: 29880490 Link
Coquet JM. Factoring in CD4 T cells during treatment of HIV. Immunol Cell Biol. May 16. DOI: 10.1038/icb.2017.37 Link
Chen T, Tibbitt CA Feng X, Stark JM, Rohrbeck L, Rausch L, Sedimbi S, Karlsson M, Lambrecht BN, Karlsson Hedestam G, Hendriks RW, Chambers B, Nylén S and Coquet JM. PPAR-gamma promotes type 2 immune responses in allergy and nematode infection. Science Immunology. 2017 10March;2(9):DOI:10.1126/sciimmunol-aal5196 Link
Carow B, Gao Y, Coquet JM, Reilly M and Rottenberg ME. Lck-driven Cre expression alters thymic T cell development, and frequencies and activation of peripheral T cell subsets. J Immunol. 2016 Aug 8, PMID: 27503210 Link
Drennan MB, Govindarajan S, Verheugen E, Coquet JM, McGuire C, Staal J, Beyaert R, van Loo G, Lambrecht BN, Elewaut D. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20. J Exp Med. 2016 Aug 22;213(10) Link
Tibbitt C and Coquet JM. House dust mite extract and cytokine instillation of mouse airways and subsequent cellular analysis. Bio-protocol. 2016;6(14):e1875 Link
Coquet JM, Schuijs M, Smyth MJ, Deswarte K, Beyaert R, Braun H, Boon L, Karlsson Hedestam GB, Nutt SL, Hammad H, Lambrecht BN. Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites. Immunity. 2015;43:318-30. Link
Coquet JM, Rausch L and Borst J. The importance of co-stimulation in the orchestration of T helper cell differentiation. Immunol Cell Biol. 2015;93:780-8. Review Link