I’ve always been interested in the plasticity of the immune response. This led me to do a PhD project in Dale Godfrey’s lab at the University of Melbourne, where i worked on cytokine production by NKT cells. I performed a couple of postdocs under Jannie Borst in Amsterdam and Bart Lambrecht in Ghent, focussed on understanding T helper cell biology and in 2014, started my own group at the Karolinska Institute. I am still interested in understanding the factors that influence cell fate, especially in T cells.
Chris’ primary interests are in studying the dynamics of T helper cell differentiation and plasticity. His research focuses on the application of single cell RNA sequencing to gain insights into the heterogeneity of T helper responses occurring during airway inflammation. With experience in murine models of asthma and arthritis, he is increasingly focussing on applying single cell analysis in clinical settings.
Leona has a strong interest in understanding the underlying molecular mechanisms leading to cancer. She did her PhD in the laboratory of Andreas Strasser at the Walter and Eliza Hall Institute in Melbourne where she researched how pro-apoptotic proteins contribute to drug sensitivity and resistance in melanoma. She now applies CRISPR/Cas9 technology to identify novel regulators of cancer and immune cell function. She is also investigating the role of short chain fatty acids in health and disease.
Julian did his MSc in biology at the University of Hohenheim, Germany, after which he completed an eight month internship in Gunilla Karlsson Hedestam’s group working on B cell defects in mice. He started his PhD in 2015 and his work has been focussed on understanding the role of cellular metabolism in the differentiation and function of Th2 cells. He is also developing new models of airway inflammation.
Junjie was awarded the Chinese Scholarship Council (CSC) fellowship and started his PhD in 2017. Junjie is developing novel models and pipelines for high throughput analysis of gene function in CD4 and CD8 T cells, in the settings of asthma and cancer.