Identifying a Th2 cell gene signature in response to house dust mites
In one of our latest studies, we probe T helper cell differentiation to house dust mite using scRNA-Seq. This defines several subsets and states of T helper cells, including Th2 cells in the airways. The genes expressed by Th2 cells in the airways include some of the usual suspects like Il5 and Il13, but many genes not previously associated with type 2 immunity are also highly specific to Th2 cells. Check it out here.