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The group @ Biomedicum

Single-cell analysis pinpoints distinct populations of cytotoxic CD4+ T cells and an IL-10+CD109+ TH2 cell population in nasal polyps

Fig. 1A from Ma, Tibbitt et al., Science Immunology 2021

Other published studies

Latest work

We recently undertook a single cell RNA-Sequencing analysis of CD4 T cells and ILC2 from nasal polyp tissue of patients with chronic rhinosinusitis

1. We resolve several canonical subsets of T helper cells including Th2, Treg, Tfh cells and 3 distinct CD4 CTL clusters.

2. CD4 CTL have the highest levels of clonal expansion and have distinct patterns of granzyme expression.

3. Th2 cells and ILC2 are profiled side-by-side, displaying several similarities and some differences. Within Th2 cells, we identify a CD109+IL-10+ state, likely reflective of Tr1 cells.

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EVENTS

12th November, 2021

Julian Stark celebrates his graduation at Stadhuset.

1st September, 2021

Javiera Alvarez Moran starts her PhD in our group.

15th November, 2020

After a hot pursuit, Egon Urgard started in our group.